I read every single one of them, as they appeared. 12, I believe. I've read them in Spanish & English! Are they true? I think each one has to make that decision for himself. I think they are, you couldn't invent that.
The drugs only appear in the first couple of books - Don Juan was trying to expand Carlos' mind, as he couldn't see any other way of doing it.
A lot of murky 'history' has come out since he died (of liver cancer allegedly), but everyone seems to have a different take on it. I think in the world of the sorcerer, things are not what they seem.